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K 2 Studien

Menaquinone-7 supplementation improves arterial stiffness in healthy postmenopausal women: double-blind randomised clinical trial

M. H. J. Knapen (1), L. A. J. L. M. Braam (1), N. E. Drummen (1), O. Bekers (2), A. P. G. Hoeks (3), C. Vermeer (1)

(1) VitaK & Cardiovascular Research Institute (CARIM), Maastricht University, The Netherlands; (2) Central Diagnostic Laboratory, University Hospital Maastricht, The Netherlands; (3) Biomedical Engineering, Maastricht University, The Netherlands

Keywords

carotid intima-media thickness, Arterial stiffness, menaquinone-7, pulse wave velocity, Stiffness Index β

Summary

Observational data suggest a link between menaquinone (MK, vitamin K2) intake and cardiovascular (CV) health. However, MK intervention trials with vascular endpoints are lacking. We investigated long-term effects of MK-7 (180 µg MenaQ7/day) supplementation on arterial stiffness in a double-blind, placebo-controlled trial. Healthy postmenopausal women (n=244) received either placebo (n=124) or MK-7 (n=120) for three years. Indices of local carotid stiffness (intima-media thickness IMT, Diameter end-diastole and Distension) were measured by echotracking. Regional aortic stiffness (carotid-femoral and carotid-radial Pulse Wave Velocity, cfPWV and crPWV, respectively) was measured using mechanotransducers. Circulating desphospho-uncarboxylated matrix Gla-protein (dp-ucMGP) as well as acute phase markers Interleukin-6 (IL-6), high-sensitive C-reactive protein (hsCRP), tumour necrosis factor-α (TNF-α) and markers for endothelial dysfunction Vascular Cell Adhesion Molecule (VCAM), E-selectin, and Advanced Glycation Endproducts (AGEs) were measured. At baseline dp-ucMGP was associated with IMT, Diameter, cfPWV and with the mean z-scores of acute phase markers (APMscore) and of markers for endothelial dysfunction (EDFscore). After three year MK-7 supplementation cfPWV and the Stiffness Index β significantly decreased in the total group, whereas distension, compliance, distensibility, Young’s Modulus, and the local carotid PWV (cPWV) improved in women having a baseline Stiffness Index β above the median of 10.8. MK-7 decreased dp-ucMGP by 50 % compared to placebo, but did not influence the markers for acute phase and endothelial dysfunction. In conclusion, long-term use of MK-7 supplements improves arterial stiffness in healthy postmenopausal women, especially in women having a high arterial stiffness.

 

Wissenschaftliche Studien zu Vitamin D 3:  - 
http://d.mp3vhs.de/vonabisw/Vitamind3/Wi/Wi1.pdf  - 
http://d.mp3vhs.de/vonabisw/Vitamind3/Wi/Wi2.pdf  - 
http://d.mp3vhs.de/vonabisw/Vitamind3/Wi/Wi3.pdf    -
http://d.mp3vhs.de/vonabisw/Vitamind3/Wi/Wi4.pdf  - 
http://d.mp3vhs.de/vonabisw/Vitamind3/Wi/Wi5.pdf  -
http://d.mp3vhs.de/vonabisw/Vitamind3/Wi/Wi6.pdf  - 
http://d.mp3vhs.de/vonabisw/Vitamind3/Wi/Wi7.pdf  -
http://d.mp3vhs.de/vonabisw/Vitamind3/Wi/Wi8.pdf  -  
 http://d.mp3vhs.de/vonabisw/Vitamind3/Wi/Wi9.pdf  - 
http://d.mp3vhs.de/vonabisw/Vitamind3/Wi/Wi10.pdf  -
Ausführliche Sammlung

http://d.mp3vhs.de/vonabisw/Vitamind3/Wi/Wi21.docx
http://d.mp3vhs.de/vonabisw/Vitamind3/Wi/Wi22.pdf  - 

http://d.mp3vhs.de/vonabisw/Vitamind3/Wi/Wi17.pdf  - 
http://d.mp3vhs.de/vonabisw/Vitamind3/Wi/Wi22.pdf  - 
http://d.mp3vhs.de/vonabisw/Vitamind3/Wi/Wi23.pdf  - 
http://d.mp3vhs.de/vonabisw/Vitamind3/Wi/Wi24.pdf  - 

http://d.mp3vhs.de/vonabisw/Vitamind3/Wi/Wi25.docx
http://d.mp3vhs.de/vonabisw/Vitamind3/Wi/Wi27.pdf
http://d.mp3vhs.de/vonabisw/Vitamind3/Wi/Wi28.pdf
http://d.mp3vhs.de/vonabisw/Vitamind3/Wi/Wi29.pdf
http://d.mp3vhs.de/vonabisw/Vitamind3/Wi/Wi30.pdf
http://d.mp3vhs.de/vonabisw/Vitamind3/Wi/Wi31.pdf
http://d.mp3vhs.de/vonabisw/Vitamind3/Wi/Wi32.pdf
http://d.mp3vhs.de/vonabisw/Vitamind3/Wi/Wi33.pdf
http://d.mp3vhs.de/vonabisw/Vitamind3/Wi/Wi34.pdf
http://d.mp3vhs.de/vonabisw/Vitamind3/Wi/Wi35.pdf
http://d.mp3vhs.de/vonabisw/Vitamind3/Wi/Wi36.pdf
http://d.mp3vhs.de/vonabisw/Vitamind3/Wi/Wi37.pdf
http://d.mp3vhs.de/vonabisw/Vitamind3/Wi/Wi38.pdf
http://d.mp3vhs.de/vonabisw/Vitamind3/Wi/Wi39.pdf
http://d.mp3vhs.de/vonabisw/Vitamind3/Wi/Wi40.pdf
http://d.mp3vhs.de/vonabisw/Vitamind3/Wi/Wi41.pdf
http://d.mp3vhs.de/vonabisw/Vitamind3/Wi/Wi42.pdf
http://d.mp3vhs.de/vonabisw/Vitamind3/Wi/Wi43.pdf

 

 

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Aktueller Forschungsstand zu Vitamin K 2:

http://www.orthoknowledge.eu/vitamin-k-vielseitiger-als-bisher-gedacht/

http://www.mikronaehrstoff.de/pdf/Groe_Kis_Vitamin_K_2014.pdf?v=1

http://www.schallers-gesundheitsbriefe.de/archiv-der-gesundheitsbriefe/archiv-12/neue-erkenntnisse-zu-vitamin-k2-teil-1/

http://www.lef.org/Magazine/2010/11/The-Remarkable-Anticancer-Properties-of-Vitamin-K/Page-01

http://josef-stocker.de/Vitamin_K.pdf

http://healthimpactnews.com/2015/vitamin-k1-and-k2-two-underappreciated-nutrients-that-are-crucial-for-health/

http://www.vitamindwiki.com/Overview+Vitamin+K+and+Vitamin+D#Vitamin_K1_phylloquinone_phytomenadione_phytonadione

http://www.vitamindwiki.com/Price+and+Masterjohn+on+Vitamin+A+Vitamin+D+and+Vitamin+K+%E2%80%93+2010

http://www.vitamindwiki.com/2,000,000+IU+Vitamin+D+was+not+a+problem+-+Sept+2014

 

___________

 

 

Update zu Vitamin K2:
http://d.mp3vhs.de/vonabisw/Vitamind3/K40.pdf

 

Dr. Kate Rhéaume-Bleue:  Vitamin K2 and the Calcium Paradox: How a Little-Known Vitamin Could Save Your Life, 2013


http://www.amazon.de/Vitamin-Calcium-Paradox-Little-Known-Rheaume-Bleue/dp/B00M0DFI7U/ref=sr_1_2?s=books&ie=UTF8&qid=1417689377&sr=1-2&keywords=Kate+Rh%C3%A9aume-Bleue


On the Trail of the Elusive X-Factor: ASixty-Two-Year-Old Mystery Finally Solved


http://www.westonaprice.org/health-topics/abcs-of-nutrition/on-the-trail-of-the-elusive-x-factor-a-sixty-two-year-old-mystery-finally-solved/ 
 
http://d.mp3vhs.de/vonabisw/k2/k32.docx

"Vitamin K 2 is the substance that makes the vitamin A- and vitamin D-dependent proteins come to life. While vitamins A and D act as signaling molecules, telling cells to make certain proteins, vitamin K 2 activates these proteins by conferring upon them the physical ability to bind calcium. In some cases these proteins directly coordinate the movement or organization of calcium themselves; in other cases the calcium acts as a glue to hold the protein in a certain shape. 33 In all such cases, the proteins are only functional once they have been activated by vitamin K."

"Vitamin K 2 may also be required for the safety of vitamin D. The anorexia, lethargy, growth retardation, bone resorption, and soft tissue calcification that animals fed toxic doses of vitamin D exhibit bear a striking resemblance to the symptoms of deficiencies in vitamin K or vitamin K-dependent proteins. Warfarin, which inhibits the recycling of vitamin K, enhances vitamin D toxicity and exerts a similar type of toxicity itself. Similarly, the same compounds that inhibit the toxicity of Warfarin also inhibit the toxicity of vitamin D. I have therefore hypothesized elsewhere that vitamin D toxicity is actually a relative deficiency of vitamin K 2. 39 The synergy with which vitamin K 2 interacts with vitamins A and D is exactly the type of synergy that Price attributed to Activator X."

http://www.zentrum-der-gesundheit.de/vitamin-k-ia.html


http://www.vitamin-k2.info/


http://www.orthoknowledge.eu/update_vitamin_k2/


http://www.lef.org/en/Magazine/2008/3/Protecting-Bone-And-Arterial-Health-With-Vitamin-K2/Page-01


http://lpi.oregonstate.edu/infocenter/vitamins/vitaminK/


http://www.nlm.nih.gov/medlineplus/druginfo/natural/983.html


http://products.mercola.com/vitamin-k/


http://www.whfoods.com/genpage.php?tname=nutrient&dbid=112


http://chriskresser.com/vitamin-k2-the-missing-nutrient


http://www.eesom.com/go/G7D6FNSK3O9DQ8N71FA0ARERG7DIKA3B

https://www.bulletproofexec.com/106-the-powers-of-vitamin-k2-with-dr-kate-rheaume-bleue-podcast/


http://doctorkatend.com/about/


https://www.youtube.com/watch?v=fYMExQNosTQ


https://www.youtube.com/watch?v=Vbd8FqnVT4c


https://www.youtube.com/watch?v=4IFhW2C1IUk


https://www.youtube.com/watch?v=dNVK1QHegb4


https://www.youtube.com/watch?v=lC3Ecx56tqE


https://www.youtube.com/watch?v=QGEg6e80WYM

 

Vitamin K:
http://de.wikipedia.org/wiki/Vitamin_K


http://josef-stocker.de/Vitamin_K.pdf


http://naturafoundation.net/monografie/Vitamin_K_K1_und_K2.html


http://www.uni-leipzig.de/~biophys/fach2/vitamine.pdf


https://www.wdr.de/tv/quarks/global/pdf/Q_Vitamine.pdf


http://www.dr-moosburger.at/pub/pub067.pdf


http://www.dr-moosburger.at/pub/pub065.pdf


http://www.dr-moosburger.at/pub/pub066.pdf


http://www.dr-moosburger.at/pub/pub069.pdf


http://www.dr-moosburger.at/publikationen.php


http://www.dr-moosburger.at/pub/pub115.pdf


http://www.dr-moosburger.at/pub/pub121.pdf